Description

1-(2-Chloroethyl)-3-(Trifluoromethyl)Benzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a reactive chloroethyl side chain with a stable, electron-withdrawing trifluoromethylbenzene core, enabling precise chemical modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of specialty electronic chemicals for display technologies, contributing to the molecular framework of charge-transport or emissive layers.
• Organic Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic systems used in cross-coupling and other transformative reactions.
• Fluorine Chemistry Research: An essential reagent for studying the introduction and effects of fluorine atoms in aromatic systems, valuable for tuning physicochemical properties like lipophilicity and metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale commercial batches.

Basic Information

Product Name	1-(2-Chloroethyl)-3-(Trifluoromethyl)Benzene
CAS No.	402-35-7
Molecular Formula	C9H8ClF3
Molecular Weight	208.61 g/mol
Synonyms	3-(Trifluoromethyl)phenethyl chloride; 2-Chloro-1-[3-(trifluoromethyl)phenyl]ethane; 1-Chloro-2-[3-(trifluoromethyl)phenyl]ethane; m-Trifluoromethylphenethyl Chloride; (3-Trifluoromethylphenyl)ethyl chloride; α-Chloro-3-(trifluoromethyl)toluene; β-Chloroethyl-3-trifluoromethylbenzene; 402-35-7
EINECS	Contact for details

Quality Control

Our 1-(2-Chloroethyl)-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.