Description

3-(Trifluoromethyl)Benzyl Bromide is a versatile organobromine building block characterized by its reactive benzyl bromide group and electron-withdrawing trifluoromethyl substituent. This combination makes it a critical intermediate for introducing the pharmaceutically valuable 3-(trifluoromethyl)benzyl moiety into more complex molecular architectures. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for synthesis and scale-up.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of compounds targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its ability to modify electronic properties.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating biaryl structures.
• Ligand & Catalyst Development: Employed in the synthesis of specialized phosphine and nitrogen-based ligands for asymmetric catalysis.
• Polymer Modification: Used to introduce fluorinated benzyl groups into polymer chains to alter surface properties, chemical resistance, and thermal stability.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel fluorinated compounds.

Basic Information

Product Name	3-(Trifluoromethyl)Benzyl Bromide
CAS No.	402-23-3
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	α-Bromo-3-(trifluoromethyl)toluene; (3-(Trifluoromethyl)phenyl)methyl bromide; 1-(Bromomethyl)-3-(trifluoromethyl)benzene; m-(Trifluoromethyl)benzyl bromide; 3-Trifluoromethylbenzyl bromide; 3-CF3-Benzyl Bromide; m-Trifluoromethylbenzyl Bromide
EINECS	206-933-5

Quality Control

Our 3-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.