Description

3,5-Bis(Trifluoromethyl)Benzaldehyde is a high-value fluorinated aromatic building block characterized by its two electron-withdrawing trifluoromethyl groups. This compound matters for its unique reactivity, serving as a critical precursor in synthesizing complex molecules where the introduction of lipophilicity and metabolic stability is paramount. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the CF3 groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine and N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Functional Material Precursor: Employed in the synthesis of organic electronic materials, such as OLED emitters and charge-transport molecules.
• Cross-Coupling Reactions: An essential substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzaldehyde
CAS No.	401-95-6
Molecular Formula	C9H4F6O
Molecular Weight	242.12 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzaldehyde; α,α,α,α',α',α'-Hexafluoro-3,5-xylylaldehyde; 3,5-Di(trifluoromethyl)benzaldehyde; Benzaldehyde, 3,5-bis(trifluoromethyl)-; 3,5-Bis(trifluoromethyl)benzenecarboxaldehyde; 1,3-Bis(trifluoromethyl)-5-formylbenzene; 3,5-BTFMBAL
EINECS	206-935-4

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzaldehyde is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider under an inert atmosphere such as nitrogen or argon. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.