Description

Ly-364947 is a potent and selective small molecule inhibitor of the TGF-β type I receptor ALK5, widely used in biochemical and pharmacological research. This compound is a critical tool for investigating the TGF-β signaling pathway, which plays a fundamental role in cell growth, differentiation, and fibrosis. It is essential for researchers and developers in the fields of academic research, pharmaceutical R&D, and biotechnology, particularly for studies targeting cancer, fibrosis, and developmental biology.

Application

• Biochemical Research: A key reagent for studying TGF-β/Activin/Nodal signaling pathways and their inhibition in vitro.
• Pharmaceutical Development: Used as a reference standard and lead compound in drug discovery programs targeting fibrotic diseases and certain cancers.
• Cell Biology Studies: Employed to modulate cell differentiation, proliferation, and epithelial-mesenchymal transition (EMT) in various cell culture models.
• Target Validation: Serves as a pharmacological tool to validate ALK5 as a therapeutic target in preclinical disease models.
• Academic Research: Facilitates fundamental research into developmental biology and tissue homeostasis mechanisms.

Basic Information

Product Name	Ly-364947
CAS No.	396129-53-6
Molecular Formula	C₂₂H₁₈N₄O₃
Molecular Weight	386.40 g/mol
Synonyms	HTS 466284; LY-364947; 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide; 2-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; TGF-β Receptor I Kinase Inhibitor IV; ALK5 Inhibitor II; SB-431542 analog
EINECS	Contact for details

Quality Control

Our Ly-364947 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee the integrity of your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.