Description

2,2,2-Trifluoro-1-(Pyridin-4-Yl)Ethan-1-Ol is a high-value fluorinated pyridine derivative, serving as a critical chiral building block in advanced organic synthesis. Its trifluoromethyl and pyridine moieties are essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity.
• Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands used in asymmetric catalysis.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties.
• Fluorine Chemistry Studies: Employed in academic and industrial R&D to study the effects of fluorination on molecular properties and reactivity.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Pyridin-4-Yl)Ethan-1-Ol
CAS No.	394203-58-8
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	4-(1-Hydroxy-2,2,2-trifluoroethyl)pyridine; 4-(2,2,2-Trifluoro-1-hydroxyethyl)pyridine; α-(Trifluoromethyl)-4-pyridinemethanol; 1-(4-Pyridinyl)-2,2,2-trifluoroethanol; Trifluoro(4-pyridyl)ethanol; TFPE; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(Pyridin-4-Yl)Ethan-1-Ol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Enantiomer Specific)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.