Description

Tiplaxtinin is a potent and selective small-molecule inhibitor of plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system. This compound is a valuable research tool for investigating the role of PAI-1 in thrombosis, fibrosis, and other pathological conditions. It is primarily utilized by pharmaceutical researchers and discovery scientists in the fields of cardiovascular disease, metabolic disorders, and oncology.

Application

• Biomedical Research: Used as a selective PAI-1 inhibitor to study fibrinolysis, thrombosis, and vascular biology in in vitro and in vivo models.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the development of novel antithrombotic and anti-fibrotic therapeutic agents.
• Mechanistic Studies: Employed to elucidate the signaling pathways and physiological roles of PAI-1 in disease progression, including cancer metastasis and tissue remodeling.
• Academic Research: A critical reagent for universities and research institutions exploring novel targets for cardiovascular and metabolic diseases.
• Preclinical Evaluation: Used in animal studies to validate PAI-1 as a therapeutic target and assess the efficacy of pharmacological inhibition.

Basic Information

Product Name	Tiplaxtinin
CAS No.	393105-53-8
Molecular Formula	C₂₀H₁₈N₂O₄S
Molecular Weight	382.44 g/mol
Synonyms	PAI-039; PAI-1 Inhibitor; Tiplaxtinin (PAI-039); 1-Benzothiophene-2-carboxamide, N-[(3aR,4S,7R,7aS)-1,3-dioxooctahydro-1H-4,7-epoxyisoindol-2(3H)-yl]-; (3aR,4S,7R,7aS)-2-[([1]benzothiophene-2-carbonyl)amino]-4,7-epoxyisoindole-1,3-dione; PAI-1 Inhibitor, Tiplaxtinin; Benzothiophene-2-carboxamide, N-[(3aR,4S,7R,7aS)-1,3-dioxooctahydro-1H-4,7-epoxyisoindol-2-yl]-
EINECS	Contact for details

Quality Control

Our Tiplaxtinin is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.