Description

Spliceostatin A CAS NO 391611-36-2 is a potent and selective small-molecule inhibitor of the spliceosome, specifically targeting the SF3b complex. This compound matters as a critical research tool for studying pre-mRNA splicing mechanisms, a fundamental biological process with implications in cancer, genetic diseases, and virology. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oncology drug discovery and molecular biology research.

Application

• Biomedical Research: Used as a chemical probe to investigate the molecular mechanisms of pre-mRNA splicing and spliceosome assembly.
• Oncology Studies: Employed in cancer research to study the effects of splicing inhibition on tumor cell proliferation, apoptosis, and metastasis.
• Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening campaigns for novel anti-cancer therapeutics targeting the spliceosome.
• Mechanistic Biology: Applied in cellular and biochemical assays to validate targets and understand the role of alternative splicing in disease pathology.
• Virology Research: Utilized to study host-virus interactions, as many viruses depend on the host splicing machinery for replication.

Basic Information

Product Name	Spliceostatin A
CAS No.	391611-36-2
Molecular Formula	C₃₄H₅₄O₉
Molecular Weight	606.79 g/mol
Synonyms	Spliceostatin A; FR901464; (3E,5E,7E,9E,11E,13E,15E,17E,19E)-20-[(1S,2R,3S,4S,5R)-3,4-Dihydroxy-2,5-dimethyl-1-[(2S)-2-methylbutanoyl]oxyhexyl]-3,5,7,9,11,13,15,17,19-nonamethyl-20-oxoicosa-3,5,7,9,11,13,15,17,19-nonaenoic acid; FR 901464
EINECS	Contact for details

Quality Control

Our Spliceostatin A is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The material is hygroscopic and must be kept in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.