Description

Pifithrin-α, p-Nitro is a potent and selective small-molecule inhibitor of p53, a critical tumor suppressor protein. This compound is a vital research tool for studying cellular apoptosis, DNA damage response, and cancer biology pathways. It is primarily utilized by researchers and scientists in the fields of oncology, molecular biology, and pharmaceutical development to investigate p53-mediated processes and potential therapeutic interventions.

Application

• Biomedical Research: A key reagent for investigating the role of p53 in apoptosis, cell cycle arrest, and senescence in various cell lines.
• Oncology Studies: Used to inhibit p53 activity in experimental models to understand tumor development, chemoresistance, and to evaluate p53-independent cell death mechanisms.
• Neuroprotection Research: Applied in studies exploring p53's role in neuronal cell death following ischemic injury or neurodegenerative conditions.
• Cardioprotection Assays: Utilized in models of myocardial infarction to examine the contribution of p53-dependent apoptosis to tissue damage.
• Drug Discovery & Screening: Serves as a reference compound and a pharmacological tool in high-throughput screens for novel p53 pathway modulators.
• Stem Cell Research: Employed to manipulate p53 signaling to control stem cell fate, including proliferation, differentiation, and genomic stability.

Basic Information

Item	Detail
Product Name	Pifithrin-α, p-Nitro
CAS No.	389850-21-9
Molecular Formula	C14H11N3O3S
Molecular Weight	301.32 g/mol
Synonyms	Pifithrin-α p-Nitro; PFT-α p-Nitro; 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone p-Nitro derivative; p53 Inhibitor Pifithrin-α p-Nitro; Pifithrin Hydrobromide p-Nitro analog; PFTα p-Nitro; NSC 146109 p-Nitro derivative
EINECS	Contact for details

Quality Control

Our Pifithrin-α, p-Nitro is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). A Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided to ensure it meets the exacting standards required for critical life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. The product is light-sensitive and should be handled accordingly to maintain potency.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.