Description

Nf449 CAS NO 389142-38-5 is a potent and selective small-molecule inhibitor of soluble guanylyl cyclase (sGC), a key enzyme in the nitric oxide signaling pathway. This compound is crucial for researchers investigating cardiovascular physiology, smooth muscle relaxation, and cellular signaling mechanisms. It is primarily utilized in biochemical research, pharmaceutical development, and as a high-purity reference standard in analytical laboratories.

Application

• Biochemical Research: A critical tool for studying the role of soluble guanylyl cyclase (sGC) in nitric oxide (NO)-mediated signaling cascades.
• Cardiovascular Pharmacology: Used in vitro and in vivo models to investigate vasodilation, blood pressure regulation, and potential therapeutic targets for hypertension.
• Smooth Muscle Physiology: Employed to elucidate mechanisms of smooth muscle relaxation in various tissues, including vascular, bronchial, and gastrointestinal systems.
• Pharmaceutical R&D: Serves as a reference compound and starting point for the development of novel therapeutics targeting the NO-sGC pathway.
• Analytical Standard: Used as a high-purity certified reference material (CRM) for method development and quality control in HPLC, LC-MS, and other analytical techniques.
• Cell Signaling Studies: Applied in cellular assays to dissect the downstream effects of cGMP production and its impact on cellular function.

Basic Information

Product Name	Nf449
CAS No.	389142-38-5
Molecular Formula	C₃₂H₄₀N₁₀O₂₀S₈
Molecular Weight	1229.36 g/mol
Synonyms	NF 449; 8-[(Phenylamino)carbonyl]amino]naphthalene-1,3,5-trisulfonic acid, tetrasodium salt; 1,3,5-Naphthalenetrisulfonic acid, 8-[[(phenylamino)carbonyl]amino]-, tetrasodium salt; sGC inhibitor NF449; NF-449; NF 449 tetrasodium salt; Phenylcarbamoylated suramin analog
EINECS	Contact for details

Quality Control

Our Nf449 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed specifications for traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.