Description

Proteasome Inhibitor Xvi is a potent, cell-permeable, and reversible inhibitor of the 20S proteasome's chymotrypsin-like activity. This compound is a critical research tool for studying proteasome function, ubiquitin-proteasome pathway signaling, and protein degradation mechanisms in cellular systems. It is essential for researchers in pharmaceutical R&D, biochemistry, and molecular biology who are investigating cancer, neurodegenerative diseases, and other conditions linked to proteasomal dysregulation.

Application

• Biochemical Research: A standard tool for in vitro and cell-based assays to study proteasome inhibition kinetics and mechanism of action.
• Drug Discovery & Development: Used as a reference compound and pharmacological probe in screening programs for novel anti-cancer therapeutics.
• Cancer Biology Studies: Employed to induce apoptosis and study cell cycle arrest in various cancer cell lines to understand tumor biology.
• Neurodegenerative Disease Research: Applied in models of diseases like Alzheimer's and Parkinson's to investigate the role of protein aggregation and clearance.
• Immunology Research: Used to study NF-κB signaling pathways, which are regulated by proteasome-mediated degradation of inhibitory proteins.
• Academic Research: A key reagent for university and institutional labs exploring fundamental cellular processes and disease mechanisms.

Basic Information

Product Name	Proteasome Inhibitor Xvi
CAS No.	389064-25-9
Molecular Formula	C₂₀H₂₇N₃O₅
Molecular Weight	389.45 g/mol
Synonyms	Bortezomib derivative Xvi; Proteasome Inhibitor XVI; (1R)-4-Methyl-1-({(2S)-3-methyl-1-[(2S)-2-[(2-pyridinylcarbonyl)amino]propanoyl]-2-piperidinyl}carbonyl)-2-(2-morpholinyl)butylboronic acid; MG-132 derivative; PS-341 analog; Z-Leu-Leu-Leu-B(OH)₂ derivative; 20S Proteasome Inhibitor Xvi
EINECS	Contact for details

Quality Control

Our Proteasome Inhibitor Xvi is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.