Description

Trka Inhibitor CAS NO 388626-12-8 is a potent and selective small molecule inhibitor targeting the Tropomyosin receptor kinase A (TrkA). This compound is crucial for researchers investigating the NGF/TrkA signaling pathway, which plays a significant role in pain sensation, neuronal development, and certain cancers. It is an essential tool for biochemical and cellular research in neuroscience, oncology, and drug discovery.

Application

• Biochemical Research: Used as a selective tool to inhibit TrkA kinase activity in in vitro enzyme assays.
• Cellular Studies: Applied in cell culture to study the downstream effects of NGF/TrkA pathway blockade on cell proliferation, differentiation, and apoptosis.
• Neuroscience Research: Investigates the role of TrkA in pain pathways, neuroinflammation, and neurodegenerative disease models.
• Oncology Research: Explores the therapeutic potential of TrkA inhibition in cancers where TrkA is overexpressed or involved in oncogenic signaling, such as certain neuroblastomas and prostate cancers.
• Drug Discovery: Serves as a reference compound or lead structure for the development of novel Trk family kinase inhibitors.
• Signal Transduction Analysis: A key reagent for mapping kinase signaling networks and understanding crosstalk with other pathways.

Basic Information

Product Name	Trka Inhibitor CAS NO 388626-12-8
CAS No.	388626-12-8
Molecular Formula	C₂₀H₂₀F₃N₅O₂
Molecular Weight	419.40 g/mol
Synonyms	ARRY-470; ARRY470; ARRY 470; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-N-methyl-; TrkA Kinase Inhibitor; NGF Receptor Inhibitor; Tropomyosin receptor kinase A inhibitor
EINECS	Contact for details

Quality Control

Our Trka Inhibitor is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry and NMR. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.