Description

5-[2-(Trifluoromethyl)Phenyl]Isoxazole CAS NO 387824-51-3 is a specialized fluorinated heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethylphenyl group fused to an isoxazole ring, makes it a valuable intermediate for developing novel active ingredients. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors. Its properties enable the creation of compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for advanced organic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Chemical Biology Probe Development: Utilized in creating labeled compounds and molecular probes for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	5-[2-(Trifluoromethyl)Phenyl]Isoxazole
CAS No.	387824-51-3
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	5-[2-(Trifluoromethyl)phenyl]-1,2-oxazole; 5-(2-Trifluoromethylphenyl)isoxazole; 2-(Trifluoromethyl)phenyl isoxazole; Isoxazole, 5-[2-(trifluoromethyl)phenyl]-; α,α,α-Trifluoro-o-tolyl isoxazole
EINECS	Contact for details

Quality Control

Every batch of 5-[2-(Trifluoromethyl)Phenyl]Isoxazole is produced under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.