Description

6-(Trifluoromethyl)Nicotinamide is a high-purity trifluoromethyl-substituted pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique physicochemical properties imparted by the trifluoromethyl group, which is essential for modulating the bioavailability and metabolic stability of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals and active pharmaceutical ingredients (APIs).

Application

• Key synthetic intermediate in the research and development of novel pharmaceutical candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Building block for the synthesis of advanced agrochemicals, including herbicides and fungicides, where the CF3 group enhances lipophilicity and biological activity.
• Precursor in material science for creating specialty chemicals and functionalized ligands used in catalysis.
• Versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Intermediate for producing custom fine chemicals and reference standards for analytical purposes.

Basic Information

Product Name	6-(Trifluoromethyl)Nicotinamide
CAS No.	386715-35-1
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	6-(Trifluoromethyl)pyridine-3-carboxamide; 3-Carbamoyl-5-(trifluoromethyl)pyridine; Nicotinamide, 6-(trifluoromethyl)-; 5-(Trifluoromethyl)nicotinamide; 6-Trifluoromethylnicotinamide; 6-Trifluoromethyl-3-pyridinecarboxamide; 3-Pyridinecarboxamide, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.