Description

6-(Trifluoromethyl)Thionicotinamide is a specialized organofluorine building block featuring a thioamide functional group. This compound is valued for its role in the synthesis of advanced agrochemicals and pharmaceuticals, where the trifluoromethyl group imparts desirable properties like enhanced metabolic stability and lipophilicity. It is primarily sought by research institutions and chemical manufacturers in the agrochemical, pharmaceutical, and material science sectors for developing novel active ingredients and functional molecules.

Application

• Agrochemical Intermediate: A key synthon for the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thionicotinamide scaffold.
• Pharmaceutical Research: Serves as a versatile precursor in medicinal chemistry for creating potential drug candidates, particularly in areas targeting enzymes and receptors.
• Ligand and Catalyst Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its coordinating thioamide group.
• Material Science: Employed in the synthesis of advanced polymers and functional materials where fluorine incorporation is required for specific thermal or chemical resistance properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	6-(Trifluoromethyl)Thionicotinamide
CAS No.	386715-34-0
Molecular Formula	C7H5F3N2S
Molecular Weight	206.19 g/mol
Synonyms	6-(Trifluoromethyl)pyridine-3-carbothioamide; 3-Pyridinecarbothioamide, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)nicotinothioamide; 6-Trifluoromethylthionicotinamide; 6-Trifluoromethyl-3-pyridinecarbothioamide; 6-Trifluoromethylnicotinamide thioamide; 6-Trifluoromethyl-3-thiocarbamoylpyridine
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Thionicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to relevant industry standards and can support custom purity requirements for specific research or production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.