Description

2-Hydroxyethyl Nortadalafil is a key pharmaceutical intermediate and a structural analog of tadalafil. This compound matters for its critical role in the synthesis and research of advanced active pharmaceutical ingredients (APIs) targeting erectile dysfunction and pulmonary arterial hypertension. It is primarily needed by pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers engaged in the development of high-purity therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of tadalafil and its structural analogs.
• Active Pharmaceutical Ingredient (API) Research: Serves as a crucial building block for the development and scale-up of new PDE5 inhibitor candidates.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Process Chemistry: Employed in route scouting and optimization studies for more efficient API manufacturing processes.
• Academic & Contract Research: Utilized in university and CRO settings for pharmacological studies and structure-activity relationship (SAR) investigations.

Basic Information

Product Name	2-Hydroxyethyl Nortadalafil
CAS No.	385769-94-8
Molecular Formula	C₂₃H₂₅N₃O₄
Molecular Weight	407.46 g/mol
Synonyms	Nortadalafil Hydroxyethyl Analog; 2-HE-Nortadalafil; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-hydroxyethyl-6-(3,4-methylenedioxyphenyl)pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; Tadalafil Impurity; Tadalafil Related Compound; PDE5 Inhibitor Intermediate; Nortadalafil Ethanol Adduct
EINECS	Contact for details

Quality Control

Our 2-Hydroxyethyl Nortadalafil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.