Description

Bcl-2 Inhibitor CAS NO 383860-03-5 is a potent and selective small molecule compound designed to target and inhibit the B-cell lymphoma 2 (Bcl-2) protein, a key regulator of programmed cell death (apoptosis). This targeted inhibition is crucial for advancing research and development in oncology, particularly for cancers characterized by Bcl-2-mediated resistance to apoptosis. It serves as a critical research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel cancer therapeutics and understanding apoptotic pathways.

Application

• Pharmaceutical Research & Development: Core component in the discovery and preclinical evaluation of novel anti-cancer drugs targeting apoptotic pathways.
• Oncology Mechanism Studies: Used in biochemical and cellular assays to study the role of Bcl-2 protein in cancer cell survival and resistance to chemotherapy.
• High-Throughput Screening (HTS): Employed as a reference standard or active compound in screening libraries to identify new drug candidates or synergistic combinations.
• Apoptosis Research: Essential tool for investigating the intrinsic apoptotic pathway in various cell types and disease models beyond oncology.
• Biomarker Development: Aids in correlating Bcl-2 inhibition with therapeutic response, supporting companion diagnostic development.
• Academic & Institutional Research: Fundamental reagent for university labs and research institutes conducting basic science in cell biology and cancer research.

Basic Information

Product Name	Bcl-2 Inhibitor
CAS No.	383860-03-5
Molecular Formula	C23H25ClN4O3S
Molecular Weight	472.99 g/mol
Synonyms	ABT-737; Bcl-2/Bcl-xL Inhibitor, ABT-737; 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanyl-2-butanyl]amino]-3-nitrophenyl]sulfonyl]benzamide; ABT737; N-(4-(4-((4'-Chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)sulfonylphenyl)-4-(((R)-4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrobenzenesulfonamide
EINECS	Contact for details

Quality Control

Our Bcl-2 Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.