Description

Efipladib is a potent and selective inhibitor of cytosolic phospholipase A2 alpha (cPLA2α), a key enzyme in the arachidonic acid pathway. This compound matters for its significant role as a high-value research tool in studying inflammatory and lipid signaling cascades. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for inflammatory diseases, asthma, and atherosclerosis.

Application

• Biochemical Research: Used as a selective pharmacological probe to study the role of cPLA2α in cellular signaling pathways and disease models.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel anti-inflammatory agents.
• In Vitro Assays: Employed in high-throughput screening (HTS) and enzymatic inhibition assays to evaluate compound libraries.
• Mechanistic Studies: Facilitates research into eicosanoid production, lipid mediator biology, and associated inflammatory responses.
• Preclinical Research: Utilized in animal models to investigate the therapeutic potential of cPLA2α inhibition for conditions like asthma, rheumatoid arthritis, and cardiovascular diseases.

Basic Information

Product Name	Efipladib
CAS No.	381683-94-9
Molecular Formula	C₂₆H₂₈F₃N₃O₄
Molecular Weight	503.52 g/mol
Synonyms	EFIPLADIB; (S)-2-(4-((2,2-Dimethyl-1-(pyrimidin-2-yl)propyl)amino)-3-(trifluoromethyl)phenyl)propanoic acid; AZD-2716; 4-[[(1S)-2,2-Dimethyl-1-(2-pyrimidinyl)propyl]amino]-3-(trifluoromethyl)benzenepropanoic acid; (S)-2-(4-((2,2-Dimethyl-1-(pyrimidin-2-yl)propyl)amino)-3-(trifluoromethyl)phenyl)propionic acid; cPLA2α Inhibitor (AZD2716); Varespladib methyl ester impurity (S-enantiomer).
EINECS	Contact for details

Quality Control

Our Efipladib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.