Description

1-(Methoxymethyl)-3-(Trifluoromethyl)Benzene is a high-purity aromatic building block featuring both a methoxymethyl ether and a trifluoromethyl group on the benzene ring. This unique structure makes it a valuable intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Incorporated as a monomer or modifier to introduce fluorine into polymers, improving chemical resistance and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a versatile scaffold for constructing complex aromatic compounds in research.
• Fluorinated Surfactant Precursor: Used in the synthesis of specialty surfactants and surface-active agents with unique wetting and spreading characteristics.

Basic Information

Product Name	1-(Methoxymethyl)-3-(Trifluoromethyl)Benzene
CAS No.	380633-51-2
Molecular Formula	C9H9F3O
Molecular Weight	190.16 g/mol
Synonyms	3-(Trifluoromethyl)benzyl methyl ether; α-Methoxy-3-(trifluoromethyl)toluene; (3-Trifluoromethylphenyl)methoxymethane; 1-Methoxymethyl-3-trifluoromethylbenzene; m-(Trifluoromethyl)benzyl Methyl Ether; 3-Trifluoromethylbenzyl Methyl Ether; Benzene, 1-(methoxymethyl)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-(Methoxymethyl)-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.