Description

Tenovin-1 is a potent and selective small molecule inhibitor of SIRT1 and SIRT2, key enzymes in the sirtuin family involved in cellular regulation. This compound matters for researchers and developers as it provides a critical tool for modulating protein deacetylation pathways, which are implicated in aging, metabolism, and various disease states. It is primarily needed by the pharmaceutical, biotechnology, and life science research industries for drug discovery, target validation, and mechanistic studies in oncology and neurology.

Application

• Biomedical Research: A key chemical tool for studying the biological functions and therapeutic potential of sirtuin inhibition in cellular and animal models.
• Drug Discovery & Development: Used as a reference compound or lead molecule in screening assays and preclinical studies targeting SIRT1/2 for cancer, neurodegenerative diseases, and metabolic disorders.
• Mechanistic Biology: Employed to investigate the role of protein acetylation/deacetylation in gene expression, DNA repair, stress response, and apoptosis.
• Oncology Research: Explored for its potential to induce p53-mediated tumor cell senescence and apoptosis, supporting cancer therapeutic research.
• Academic & Institutional Labs: Serves as a standard reagent in university and research institute projects focused on epigenetics and signal transduction.
• Biochemical Assay Development: Utilized as a control or standard in developing high-throughput screening (HTS) platforms for sirtuin activity.

Basic Information

Product Name	Tenovin-1
CAS No.	380315-80-0
Molecular Formula	C22H29N3O2S
Molecular Weight	399.55 g/mol
Synonyms	N-(2-Mercaptophenyl)-3-nitrobenzamide; 2-[(3-Nitrobenzoyl)amino]benzenethiol; Tenovin 1; Tenovin1; SIRT1/2 Inhibitor; Sirtuin Inhibitor III; SIRT Inhibitor; 380315-80-0
EINECS	Contact for details

Quality Control

Our Tenovin-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.