Description

2-Ethynyl-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its reactive ethynyl group and electron-deficient pyridine core. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for functionalized polymers, ligands for catalysis, and advanced organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an ideal substrate for Sonogashira, Click Chemistry, and other palladium-catalyzed cross-coupling reactions.
• Ligand Synthesis: Used to prepare novel nitrogen-containing ligands for transition metal catalysis.
• Chemical Biology: Employed as a probe or tagging agent in bioconjugation and labeling studies.

Basic Information

Product Name	2-Ethynyl-5-(Trifluoromethyl)Pyridine
CAS No.	379670-42-5
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	5-(Trifluoromethyl)-2-ethynylpyridine; 2-Ethynyl-5-(trifluoromethyl)pyridine; 2-Ethynyl-α,α,α-trifluoro-5-pyridinemethanol (tautomer); 5-(Trifluoromethyl)pyridin-2-ylacetylene; Pyridine, 2-ethynyl-5-(trifluoromethyl)-; 2-Ethynyl-5-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyl-5-(Trifluoromethyl)Pyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.