Description

2,4-Bis(Trifluoromethyl)Benzenesulfonylchloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride group and electron-withdrawing trifluoromethyl substituents. This compound matters for its critical role in synthesizing advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable properties like enhanced metabolic stability and lipophilicity. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex sulfonamide derivatives and functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides, where the trifluoromethyl groups contribute to biological activity and environmental persistence.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and advanced organic electronic materials due to its aromatic and fluorinated structure.
• Chemical Research & Development: An essential reagent in organic synthesis for introducing the benzenesulfonyl moiety into complex molecules under mild conditions.
• Dye & Pigment Industry: Intermediate in the manufacture of specialized fluorinated dyes and colorants with unique stability and chromatic properties.

Basic Information

Product Name	2,4-Bis(Trifluoromethyl)Benzenesulfonylchloride
CAS No.	376637-88-6
Molecular Formula	C8H3ClF6O2S
Molecular Weight	312.62 g/mol
Synonyms	2,4-Bis(trifluoromethyl)benzenesulfonyl chloride; 2,4-Di(trifluoromethyl)benzenesulfonyl chloride; 1,3-Bis(trifluoromethyl)benzene-4-sulfonyl chloride; α,α,α,α',α',α'-Hexafluoro-2,4-xylene-ω-sulfonyl chloride; 2,4-Bis(trifluoromethyl)phenylsulfonyl chloride; 2,4-BTFBSCl; 2,4-Bis(trifluoromethyl)benzenesulphonyl chloride
EINECS	Contact for details

Quality Control

Our 2,4-Bis(Trifluoromethyl)Benzenesulfonylchloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.