Description

5-Cyano-2-Fluoro-6-Picoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its molecular architecture, featuring both cyano and fluoro substituents on the pyridine core, makes it a versatile precursor for constructing complex pharmacophores and agrochemical intermediates. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing groups.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-Cyano-2-Fluoro-6-Picoline
CAS No.	375368-85-7
Molecular Formula	C7H4FN2
Molecular Weight	136.12 g/mol
Synonyms	2-Fluoro-6-methyl-5-pyridinecarbonitrile; 5-Cyano-2-fluoro-6-methylpyridine; 6-Methyl-2-fluoro-5-cyanopyridine; 2-Fluoro-5-cyano-6-methylpyridine; 5-Pyridinecarbonitrile, 2-fluoro-6-methyl-; 2-Fluoro-6-picoline-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-Cyano-2-Fluoro-6-Picoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation by IR and NMR, and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.