Description

Mibampator CAS NO 375345-95-2 is a potent and selective positive allosteric modulator of the AMPA-type glutamate receptor. This compound is of significant interest for its potential to modulate synaptic plasticity and neurotransmission. It is primarily utilized by pharmaceutical researchers and development teams in the neuroscience and CNS drug discovery sectors for investigating cognitive disorders and neurodegenerative diseases.

Application

• Pharmaceutical Research & Development: A key investigational compound for studying AMPA receptor pharmacology and its role in synaptic function.
• Cognitive Disorder Studies: Used in preclinical research models targeting conditions such as Alzheimer's disease, cognitive impairment, and memory deficits.
• Neurodegenerative Disease Research: Employed in the investigation of potential therapeutic pathways for diseases like Parkinson's and ALS.
• Neuropharmacology Screening: Serves as a reference standard or active agent in high-throughput screening assays for novel CNS-active compounds.
• Academic Neuroscience Research: Utilized in university and institutional labs to explore fundamental mechanisms of learning, memory, and neural communication.
• Biomarker & Diagnostic Development: May be used in studies aimed at developing biomarkers related to glutamatergic system dysfunction.

Basic Information

Product Name	Mibampator
CAS No.	375345-95-2
Molecular Formula	C20H21N3O4S
Molecular Weight	399.46 g/mol
Synonyms	LY-451395; (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid; Mibampator (LY451395); LY 451395; AMPA receptor potentiator LY451395; Decahydro-6-[2-(1H-tetrazol-5-yl)ethyl]isoquinoline-3-carboxylic acid, (3S,4aR,6R,8aR)-
EINECS	Contact for details

Quality Control

Our Mibampator is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets high-grade standards suitable for research applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.