Description

Proteasome-In-1 is a potent and selective small molecule inhibitor of the proteasome complex, a critical regulator of intracellular protein degradation. This compound is a vital research tool for studying proteasome function, ubiquitin-proteasome pathway dynamics, and related disease mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and basic biochemical research.

Application

• Biochemical Research: Used as a selective inhibitor to study the structure, function, and inhibition mechanisms of the 20S proteasome.
• Drug Discovery & Development: Serves as a key pharmacological tool and reference compound in screening assays and the development of novel proteasome-targeting therapeutics.
• Cell Biology Studies: Employed to investigate the role of the ubiquitin-proteasome system in cellular processes such as cell cycle regulation, apoptosis, and signal transduction.
• Disease Mechanism Research: Facilitates research into diseases where proteasome dysfunction is implicated, including certain cancers, neurodegenerative disorders, and autoimmune conditions.
• Enzymology: Used in kinetic studies and enzymatic assays to characterize proteasome activity and the potency of novel inhibitors.

Basic Information

Product Name	Proteasome-In-1
CAS No.	374080-21-4
Molecular Formula	C₁₉H₁₈N₄O₄
Molecular Weight	366.37 g/mol
Synonyms	N-[(2S)-1-[[(2S)-4-Methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1H-indole-2-carboxamide; Proteasome Inhibitor I; MG-132 derivative; Z-Leu-Leu-Leu-al
EINECS	Contact for details

Quality Control

Our Proteasome-In-1 is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.