Description

L-Thio-Ap4 is a specialized biochemical compound with the CAS registry number 373644-25-8, serving as a stable, sulfur-containing analog of adenosine tetraphosphate. This compound is valued for its role as a potent and selective P2Y1 receptor antagonist, making it a critical tool for probing purinergic signaling pathways in biological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on cardiovascular, neurological, and inflammatory disease models.

Application

• Pharmacological Research: As a selective antagonist for the P2Y1 purinergic receptor, used to study receptor function and signal transduction mechanisms.
• Cardiovascular Studies: Investigation of platelet aggregation, thrombosis, and vascular tone regulation where P2Y1 receptors play a key role.
• Neuroscience Research: Exploration of synaptic transmission, glial cell communication, and neuroinflammatory processes mediated by purinergic signaling.
• Biochemical Assay Development: Used as a reference standard or key component in high-throughput screening (HTS) assays for drug discovery targeting P2Y receptors.
• Cell Signaling Pathway Analysis: A vital tool for dissecting the role of extracellular nucleotides in cellular communication, proliferation, and apoptosis.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in biochemistry, molecular biology, and physiology.

Basic Information

Product Name	L-Thio-Ap4
CAS No.	373644-25-8
Molecular Formula	C₁₀H₁₅N₅O₉P₃S
Molecular Weight	507.22 g/mol
Synonyms	Adenosine-5'-[tetrahydrogen triphosphate], 1-thio-, L-isomer; Adenosine 5'-(γ-thio)tetraphosphate, L-isomer; L-Adenosine-5'-tetraphospho-1-thiol; L-ATPγS tetraphosphate; P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, 1-thio-; P2Y1 receptor antagonist; (Sp)-Adenosine 5'-O-(1-thiotetraphosphate); ARL 66096 analog (thio-tetraphosphate form)
EINECS	Contact for details

Quality Control

Every batch of L-Thio-Ap4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity profiles, identity confirmation by spectroscopic methods (NMR, MS), and impurity limits. Our quality commitment ensures the material meets the stringent requirements for research and development applications, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the container to reach room temperature before opening to minimize moisture condensation. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.