Description

5-Cyano-2-Methyl-Benzenesulfonyl Chloride is a versatile and reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the sulfonamide functional group, a key moiety in the development of active pharmaceutical ingredients and specialty agrochemicals. This high-purity intermediate is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to create novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonamide group enhances bioactivity.
• Material Science Research: Employed in the creation of functional polymers and advanced materials with specific sulfonated properties.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or other biomolecules in proteomics and biochemical research.
• Dye and Pigment Manufacturing: Serves as an intermediate in the production of specialized sulfonated dyes and colorants.
• Custom Synthesis and Contract Manufacturing: A vital reagent for CROs and CDMOs producing bespoke organic molecules for client projects.

Basic Information

Item	Details
Product Name	5-Cyano-2-Methyl-Benzenesulfonyl Chloride
CAS No.	372198-49-7
Molecular Formula	C8H6ClNO2S
Molecular Weight	215.66 g/mol
Synonyms	2-Methyl-5-cyanobenzenesulfonyl chloride; 5-Cyano-o-toluenesulfonyl chloride; 2-Methyl-5-cyanophenylsulfonyl chloride; 3-Methyl-4-sulfonylchloride benzonitrile; (5-Cyano-2-methylphenyl)sulfonyl chloride; Benzenesulfonyl chloride, 5-cyano-2-methyl-; 372198-49-7
EINECS	Contact for details

Quality Control

Every batch of 5-Cyano-2-Methyl-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.