Description

Ym348 is a high-purity specialty organic compound widely utilized as a key intermediate in the synthesis of pharmaceuticals and advanced functional materials. Its structural precision and batch-to-batch consistency make it critical for applications demanding stringent chemical fidelity and reproducible reaction outcomes. Pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical manufacturers rely on Ym348 CAS NO 372163-84-3 for scalable, GMP-aligned synthetic routes — particularly in oncology and CNS-targeted drug programs.

Application

• Pharmaceutical intermediate for kinase inhibitor APIs
• Synthesis of PET radiotracer precursors in nuclear medicine
• Building block for heterocyclic compounds in antiviral drug discovery
• Key reagent in asymmetric catalysis for chiral ligand development
• Functional material precursor for organic semiconductors and OLED emitters
• Research standard in structure–activity relationship (SAR) studies
• Custom synthesis platform for PROTAC linker optimization
• High-value intermediate in process chemistry for Phase II/III clinical candidates

Basic Information

Product Name	Ym348
CAS No.	372163-84-3
Molecular Formula	C18H15F2N3O2
Molecular Weight	343.33 g/mol
Synonyms	YM-348; YM348; 3-(2,4-Difluorophenyl)-1-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one; PYR-348; DFPP-PPPO; YM348 Intermediate; 3-(2,4-Difluorophenyl)-1-(3-pyridyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one; YM-348 (research chemical)
EINECS	603-924-1

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Ym348 is verified against pharmacopeial-grade criteria including identity (IR, NMR), assay (HPLC), residual solvents (GC), heavy metals (ICP-MS), and microbiological limits where applicable. Certificates of Analysis (COA) are available upon request, and all production adheres to ISO 9001 and cGMP-aligned quality management systems. Testing conforms to USP Chapter <1058> (Analytical Instrument Qualification) and ICH Q2(R2) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under dry, inert atmosphere (nitrogen or argon) due to hygroscopic nature. Keep away from moisture sources and maintain relative humidity below 30% during handling and storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.5%
Related Substances (HPLC)	≤ 0.3% total impurities
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (Karl Fischer)	≤ 0.2%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.