Description

Ikkγ Nbd Inhibitory Peptide is a synthetic, biologically active peptide designed to selectively inhibit the IKKγ (NEMO) protein, a critical regulatory component of the NF-κB signaling pathway. This targeted inhibition makes it a valuable research tool for studying inflammatory responses, immune regulation, and oncogenesis. It is primarily utilized by researchers and developers in the fields of pharmaceutical R&D, academic biochemistry, and molecular biology for mechanistic studies and potential therapeutic discovery.

Application

• Biochemical Research: Used as a specific inhibitor to study the structure and function of the IKK complex and the NF-κB signaling cascade in vitro.
• Cell Biology Studies: Applied in cell culture models to investigate the role of NF-κB in inflammation, apoptosis, and cellular stress responses.
• Drug Discovery Screening: Serves as a reference compound or positive control in high-throughput assays designed to identify novel anti-inflammatory or anti-cancer agents.
• Target Validation: Employed to confirm the biological role of IKKγ/NEMO in specific disease models, aiding in the validation of new therapeutic targets.
• Signal Transduction Analysis: A key reagent for dissecting complex intracellular signaling networks that involve NF-κB activation.

Basic Information

Product Name	Ikkγ Nbd Inhibitory Peptide
CAS No.	372146-18-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NBD Inhibitory Peptide; IKKγ NBD Peptide; NEMO-Binding Domain Peptide; NF-κB Essential Modulator Inhibitory Peptide; IKKγ Inhibitor; NBD Peptide; Cell-permeable NEMO-binding domain peptide
EINECS	Contact for details

Quality Control

Our Ikkγ Nbd Inhibitory Peptide is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all quality parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in water or DMSO
Biological Activity	Tested in relevant cell-based assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.