Description

Cintredekin Besudotox CAS NO 372075-36-0 is a targeted recombinant fusion protein designed for therapeutic applications. This compound is engineered to deliver a potent cytotoxic agent specifically to cells expressing the interleukin-13 receptor, offering a mechanism for precise therapeutic intervention. It is primarily utilized in advanced pharmaceutical research and development, particularly in the field of oncology for targeted cancer therapy.

Application

• Primary research and development of targeted cancer therapeutics.
• Pre-clinical and clinical studies in oncology, specifically for glioblastoma and other solid tumors.
• Investigational use in developing treatments for diseases with overexpression of the IL-13 receptor.
• As a key reference standard in analytical and bioanalytical laboratories for method development and validation.
• Utilization in pharmacokinetic and pharmacodynamic studies for novel drug conjugates.
• Component in the formulation of specialized investigational medicinal products (IMPs).

Basic Information

Product Name	Cintredekin Besudotox
CAS No.	372075-36-0
Molecular Formula	C2540H3924N680O786S18
Molecular Weight	~57.8 kDa
Synonyms	IL13-PE38QQR; Cintredekin Besudotox; Recombinant Interleukin-13-Pseudomonas Exotoxin Fusion Protein; IL-13-PE38QQR; TP-38; Ontak (Note: Ontak is Denileukin Diftitox, a related IL-2 fusion toxin); Targeted Toxin IL13-PE38QQR; IL13-Pseudomonas Exotoxin A Fusion Protein
EINECS	Contact for details

Quality Control

Our Cintredekin Besudotox is produced and handled under stringent quality systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and biological activity assays, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) documenting purity, potency, endotoxin levels, and sterility (where applicable) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled, dry conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE / SEC-HPLC)	≥ 95%
Protein Content (UV Absorbance)	As per COA
Biological Activity (Cell-based assay)	As per COA
Endotoxin Level (LAL test)	< 1.0 EU/mg
Residual Moisture (KF)	< 3.0% (for lyophilized form)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.