Description

Pi3-Kinase α Inhibitor 2 is a potent and selective small molecule inhibitor of the phosphoinositide 3-kinase alpha (PI3Kα) isoform, a key signaling node in the PI3K/AKT/mTOR pathway. This compound is a critical research tool for investigating oncogenic signaling, cellular metabolism, and for the preclinical development of targeted cancer therapeutics. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on oncology, metabolic disorders, and signal transduction studies.

Application

• Biochemical Research: Used as a selective probe to study the specific biological functions and signaling mechanisms of the PI3Kα isoform in cell culture and in vitro assays.
• Oncology Drug Discovery: Serves as a reference compound and pharmacological tool in high-throughput screening and lead optimization programs targeting PI3K-driven cancers.
• Mechanistic Studies: Enables investigation of the role of PI3Kα in cellular processes such as proliferation, survival, glucose metabolism, and angiogenesis.
• Preclinical Development: Utilized in animal models to validate PI3Kα as a therapeutic target and to understand the pharmacodynamic effects of pathway inhibition.
• Combinatorial Therapy Research: Explored in studies combining PI3K inhibition with other targeted agents or chemotherapeutics to overcome drug resistance.

Basic Information

Product Name	Pi3-Kinase α Inhibitor 2
CAS No.	371943-05-4
Molecular Formula	C₂₄H₂₅N₇O₂
Molecular Weight	443.51 g/mol
Synonyms	PI3Kα Inhibitor 2; PIK-75; N-(3-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N'-(4-methoxyphenyl)urea; 1-(3-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea; PIK75; PI3K Inhibitor PIK-75; PI3K alpha Inhibitor PIK-75
EINECS	Contact for details

Quality Control

Our Pi3-Kinase α Inhibitor 2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.