Description

Pi-103 (Hydrochloride) is a high-purity, small molecule chemical compound primarily utilized as a key research and pharmaceutical intermediate. Its significance lies in its role as a potent and selective inhibitor of the PI3K/Akt/mTOR signaling pathway, a critical target in oncology and metabolic disease research. This product is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors working on novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of targeted cancer therapies.
• Biochemical Assays: Used as a selective inhibitor in cell-based and enzymatic assays to study the PI3K/Akt/mTOR pathway and its role in cell proliferation, survival, and metabolism.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate the efficacy and mechanism of action of PI3K pathway inhibitors.
• Chemical Synthesis: Acts as a versatile building block for the synthesis of more complex analogs and derivatives for structure-activity relationship (SAR) studies.
• Academic Research: A valuable tool for universities and research institutes investigating signal transduction, oncology, and drug resistance mechanisms.

Basic Information

Product Name	Pi-103 (Hydrochloride)
CAS No.	371935-79-4
Molecular Formula	C₂₅H₂₇N₅O₃ • HCl
Molecular Weight	474.0 g/mol (as hydrochloride salt)
Synonyms	PI-103 Hydrochloride; 2-Morpholin-4-yl-8-phenylchromen-4-one, 6-(4-Hydroxyphenyl)-7-[4-(morpholin-4-yl)phenyl]pyrido[3,4-d]pyrimidin-4(3H)-one hydrochloride; 6-(4-Hydroxyphenyl)-7-[4-(4-morpholinyl)phenyl]-4(3H)-pyrido[3,4-d]pyrimidinone hydrochloride; PI3K Inhibitor PI-103 (hydrochloride); Dual PI3K/mTOR Inhibitor PI-103 HCl
EINECS	Contact for details

Quality Control

Our Pi-103 (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.