Description

Pi-103 CAS NO 371935-74-9 is a potent and selective small molecule inhibitor primarily targeting the PI3K/Akt/mTOR signaling pathway, a critical regulator of cell growth, proliferation, and survival. This compound is valued for its high specificity and efficacy in biochemical and cellular research applications. It is an essential tool for researchers in oncology, pharmacology, and molecular biology, enabling the study of cancer mechanisms, drug resistance, and the development of targeted therapeutic strategies.

Application

• Biochemical Research: Used as a selective inhibitor to study the PI3K/Akt/mTOR signaling pathway in in vitro enzyme assays.
• Cellular Biology Studies: Applied in cell culture to investigate the effects of pathway inhibition on cell proliferation, apoptosis, and autophagy.
• Oncology Research: A key pharmacological tool for exploring tumorigenesis, validating drug targets, and assessing combination therapies in cancer models.
• Drug Discovery & Development: Serves as a reference compound and lead molecule in high-throughput screening and preclinical studies for novel anticancer agents.
• Signal Transduction Analysis: Facilitates the mapping of downstream effectors and cross-talk within complex cellular signaling networks.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on metabolic diseases, aging, and cellular homeostasis.

Basic Information

Product Name	Pi-103
CAS No.	371935-74-9
Molecular Formula	C₂₅H₂₄N₈O₂
Molecular Weight	468.52 g/mol
Synonyms	Pi-103; PI103; 2-Morpholin-4-yl-8-phenylchromen-4-one; 8-Phenyl-2-(4-morpholinyl)-4H-1-benzopyran-4-one; 8-Phenyl-2-(morpholin-4-yl)chromen-4-one; PI3K/mTOR Inhibitor; PI3K inhibitor VII; Dual PI3K/mTOR inhibitor
EINECS	Contact for details

Quality Control

Every batch of Pi-103 is manufactured under strict quality management protocols and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes results from HPLC, NMR, and mass spectrometry. We adhere to high-purity research-grade standards, ensuring reliable and reproducible performance for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.