Description

Tubulysin F CAS NO 368870-67-1 is a highly potent synthetic derivative of the naturally occurring tubulysin family of cytotoxic peptides. This compound is a critical research tool and a key intermediate in the development of next-generation antibody-drug conjugates (ADCs) and targeted cancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on oncology and novel drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent cytotoxic warhead for conjugation to monoclonal antibodies targeting specific cancer cells.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies to investigate mechanisms of action and efficacy against various cancer cell lines.
• Chemical Biology Probe: Employed to study microtubule dynamics and disruption, providing insights into cell division and cytoskeleton function.
• Drug Discovery Intermediate: Acts as a key building block for the synthesis of novel tubulysin analogs with optimized pharmacological properties.
• Potency Calibration: Utilized to calibrate bioassays and establish potency benchmarks for other cytotoxic agents in development pipelines.

Basic Information

Product Name	Tubulysin F
CAS No.	368870-67-1
Molecular Formula	C45H67N5O10S
Molecular Weight	870.11 g/mol
Synonyms	Tubulysin F; (2S,4R)-4-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-Hydroxy-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid; Tubugis F; TUB F
EINECS	Contact for details

Quality Control

Our Tubulysin F is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.