Description

Selegiline-n-Oxide is a key pharmaceutical intermediate and metabolite of the selective MAO-B inhibitor selegiline. This compound is essential for advanced research and development in neuropharmacology, serving as a critical reference standard and precursor. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for the development and quality control of neurological and psychiatric therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of selegiline and related therapeutic compounds.
• Metabolite Reference Standard: Used in analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies to identify and quantify selegiline metabolites.
• Biochemical Research: Employed in neuroscience research to study the mechanisms of monoamine oxidase inhibition and dopaminergic activity.
• Analytical Testing: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and GC-MS methods in pharmaceutical quality control.
• API Manufacturing: Used in the controlled production and impurity profiling of selegiline hydrochloride and other API formulations.

Basic Information

Product Name	Selegiline-n-Oxide
CAS No.	366462-61-5
Molecular Formula	C13H17NO2
Molecular Weight	219.28 g/mol
Synonyms	(R)-(-)-Deprenyl-N-oxide; (R)-N-((1S)-1-Methyl-2-phenylethyl)-N-(prop-2-yn-1-yl)amine oxide; Selegiline N-Oxide; (-)-Deprenyl N-Oxide; L-Deprenyl-N-oxide; J-508; J508; (R)-(-)-N,α-Dimethyl-N-2-propynylphenethylamine N-oxide
EINECS	Contact for details

Quality Control

Our Selegiline-n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling via HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.