Description

5-Isothiazolesulfonyl Chloride is a specialized heterocyclic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its high reactivity as a sulfonylation agent, enabling the efficient introduction of the isothiazole-sulfonyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with unique modes of action.
• Functional Material Precursor: Building block for creating specialized polymers, ligands, and dyes with tailored electronic or photophysical properties.
• Chemical Biology Probe Development: Employed to synthesize activity-based probes for studying enzyme function and protein interactions.
• Sulfonamide Library Synthesis: A crucial reactant for generating diverse sulfonamide compound libraries in medicinal chemistry for high-throughput screening.

Basic Information

Product Name	5-Isothiazolesulfonyl Chloride
CAS No.	362658-19-3
Molecular Formula	C3H2ClNO2S2
Molecular Weight	183.64 g/mol
Synonyms	1,2-Thiazole-5-sulfonyl chloride; Isothiazole-5-sulfonyl chloride; 5-Sulfonylchloride isothiazole; 1,2-Thiazol-5-ylsulfonyl chloride; 5-(Chlorosulfonyl)isothiazole; 5-Isothiazolesulfonic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Isothiazolesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and chemical identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.