Description

L-Methionine-D3 (S-Methyl-D3)-Methyl-D3 Sulfonium Chloride is a stable isotope-labeled derivative of the essential amino acid methionine, specifically deuterated on the methyl groups of the sulfonium moiety. This compound is a critical reagent in advanced research, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR analysis. It is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and CROs specializing in drug development, biomarker discovery, and stable isotope tracer methodologies.

Application

• Stable Isotope-Labeled Internal Standard for the accurate quantification of methionine and its metabolites in complex biological matrices via LC-MS/MS.
• Metabolic Pathway Tracing in studies of one-carbon metabolism, transmethylation reactions, and sulfur amino acid biochemistry.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research for novel drug candidates targeting metabolic disorders or cancer.
• Biomarker Discovery and Validation in clinical research for conditions related to methionine cycle dysregulation.
• NMR Spectroscopy Studies for structural and dynamic analysis of biochemical processes without spectral interference.
• Synthesis of Deuterated Pharmaceutical Intermediates for the development of labeled drug molecules.

Basic Information

Product Name	L-Methionine-D3 (S-Methyl-D3)-Methyl-D3 Sulfonium Chloride
CAS No.	362049-54-5
Molecular Formula	C6H8D6ClNO2S
Molecular Weight	213.75 g/mol
Synonyms	(S)-2-Amino-4-((trideuteriomethyl)(trideuteriomethyl)sulfonio)butanoate Chloride; L-Methionine-d6 Sulfonium Chloride; Methionine-d6 Sulfonium Chloride; (3S)-3-Amino-4-[(trideuteriomethyl)(trideuteriomethyl)sulfaniumyl]butanoate Chloride; S-Methyl-d3-methionine-d3 Sulfonium Chloride; Deuterated Methionine Sulfonium Chloride; L-Met-d6 Sulfonium Chloride
EINECS	Contact for details

Quality Control

Our L-Methionine-D3 (S-Methyl-D3)-Methyl-D3 Sulfonium Chloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D, atom %), chemical purity, and identity confirmation. We support compliance with relevant standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D, atom %)	≥ 98.0% (per position)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.