Description

Cdk4/6 Inhibitor Iv CAS NO 359886-84-3 is a potent and selective small molecule inhibitor targeting the cyclin-dependent kinases 4 and 6 (CDK4/6), key regulators of the cell cycle. This compound is a critical research tool for investigating cell cycle progression, oncogenesis, and the development of targeted cancer therapies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel CDK4/6-targeted oncology therapeutics.
• Biochemical & Cell-Based Assays: Used as a selective inhibitor to study the role of CDK4/6 in cell cycle regulation, proliferation, and senescence in various cancer cell lines.
• Mechanism of Action (MoA) Studies: Essential for elucidating signaling pathways, drug resistance mechanisms, and combination therapy strategies in cancer research.
• Preclinical Development: Employed in pharmacokinetics (PK), pharmacodynamics (PD), and efficacy studies in animal models of cancer.
• Chemical Probe for Target Validation: Aids in validating CDK4/6 as a therapeutic target for specific cancer types.
• Academic Research: Fundamental tool for molecular biology and oncology research projects in university and institutional laboratories.

Basic Information

Product Name	Cdk4/6 Inhibitor Iv
CAS No.	359886-84-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CDK4/6 Inhibitor IV; Palbociclib Isethionate; PD-0332991 Isethionate; 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt; Ibrance (Palbociclib) Isethionate; PD-0332991 Isethionate Salt; (S)-6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate
EINECS	Contact for details

Quality Control

Our Cdk4/6 Inhibitor Iv is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term storage, keep at 2-8°C. The product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment after each use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.