Description

Drinabant CAS NO 358970-97-5 is a synthetic cannabinoid receptor antagonist of significant research interest. This compound is a critical tool for investigating the endocannabinoid system and its role in various physiological and neurological pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on metabolic disorders, appetite regulation, and related therapeutic areas.

Application

• Pharmacological Research: A key reference standard and active agent in studies targeting the cannabinoid CB1 receptor.
• Drug Discovery Programs: Used in high-throughput screening and lead optimization for developing novel therapeutics for obesity and metabolic syndrome.
• Biochemical Assay Development: Serves as a precise control compound in binding affinity and functional activity assays (e.g., cAMP, GTPγS).
• Neuroscience Studies: Employed to elucidate the role of the endocannabinoid system in appetite, reward, and energy homeostasis.
• Metabolic Disorder Research: Investigated for its potential effects on lipid metabolism, insulin sensitivity, and related pathways.
• Reference Material: Provides a certified standard for analytical method development, validation, and quality control in API synthesis.

Basic Information

Product Name	Drinabant
CAS No.	358970-97-5
Molecular Formula	C₂₅H₂₅ClN₂O₂
Molecular Weight	420.93 g/mol
Synonyms	AVE 1625; 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole; 1,2,4-Triazole derivative AVE1625; Drinabant (AVE1625); 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidyl)-1H-pyrazole-3-carboxamide (related IUPAC); Cannabinoid CB1 receptor antagonist AVE-1625
EINECS	Contact for details

Quality Control

Every batch of Drinabant is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support your research, including identity confirmation by spectroscopic methods (NMR, IR, MS) and high-purity verification by HPLC. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, related substances, and residual solvents. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.