Description

2-Bromo-4-Fluoropyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms on the pyridine ring, enabling selective functionalization and the introduction of complexity into target molecules. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized nitrogen-containing ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Fluorine Chemistry Building Block: Utilized to study the effects of fluorine introduction on the physicochemical properties of heterocyclic compounds.

Basic Information

Product Name	2-Bromo-4-Fluoropyridine
CAS No.	357927-50-5
Molecular Formula	C5H3BrFN
Molecular Weight	175.99 g/mol
Synonyms	4-Fluoro-2-bromopyridine; 2-Bromo-4-fluoropyridine; 4-Fluoro-2-bromo-pyridine; Pyridine, 2-bromo-4-fluoro-; 2-Brom-4-fluorpyridin (German); 2-Bromo-4-fluoro-pyridine; 4-Fluoro-2-bromopyridine, 2-Bromo-4-fluoropyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoropyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity while monitoring for specified impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.