Description

Histone Acetyltransferase Inhibitor Iv, Cpth2 is a potent and selective small-molecule inhibitor of the p300/CBP histone acetyltransferase (HAT) family. This compound is a critical research tool for investigating epigenetic regulation, chromatin remodeling, and gene expression dynamics in cellular systems. It is primarily utilized by researchers and pharmaceutical developers in the fields of oncology, neurology, and metabolic disease research to study disease mechanisms and validate novel therapeutic targets.

Application

• Epigenetics Research: A key reagent for studying the role of histone acetylation in gene transcription, DNA repair, and cell cycle progression.
• Oncology & Cancer Biology: Used to investigate p300/CBP HAT activity in tumorigenesis, cancer cell proliferation, and as a potential target for anti-cancer drug discovery.
• Neurological Disease Models: Applied in research on neurodegenerative and neuropsychiatric disorders where epigenetic dysregulation is implicated.
• Stem Cell & Developmental Biology: Employed to modulate cellular differentiation and pluripotency by altering the epigenetic landscape.
• Inflammatory Pathway Analysis: Useful for dissecting the epigenetic control of inflammatory responses and immune cell function.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assays designed to discover new epigenetic modulators.

Basic Information

Product Name	Histone Acetyltransferase Inhibitor Iv, Cpth2
CAS No.	357649-93-5
Molecular Formula	C19H17N3O3S
Molecular Weight	367.42 g/mol
Synonyms	CPTH2; (E)-N-(4-(((2,4-Dimethoxyphenyl)amino)sulfonyl)phenyl)-3-(5-methylfuran-2-yl)acrylamide; Histone Acetyltransferase Inhibitor IV; p300/CBP HAT Inhibitor; C646 analog; Lysine Acetyltransferase Inhibitor
EINECS	Contact for details

Quality Control

Our Histone Acetyltransferase Inhibitor Iv, Cpth2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to high-purity standards suitable for biochemical and cell-based research, ensuring the product meets the stringent requirements of academic and pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (IC50)	Reported value provided

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.