Description

Sb-505124 is a potent and selective small molecule inhibitor of the TGF-β type I receptor ALK5 (activin receptor-like kinase 5). This compound is a critical research tool for investigating the TGF-β signaling pathway, which plays a fundamental role in cell growth, differentiation, and fibrosis. Researchers in pharmaceutical development, cell biology, and oncology utilize Sb-505124 to study disease mechanisms and validate therapeutic targets related to fibrosis, cancer metastasis, and immune regulation.

Application

• Biomedical Research: A key reagent for studying the role of TGF-β/ALK5 signaling in cellular processes like epithelial-mesenchymal transition (EMT), apoptosis, and cell cycle arrest.
• Drug Discovery & Target Validation: Used in high-throughput screening and functional assays to identify and validate novel compounds targeting the TGF-β pathway for therapeutic intervention.
• Fibrosis Research: Applied in in vitro and in vivo models to investigate and inhibit pathological fibrosis in organs such as the liver, kidney, and lungs.
• Cancer Biology Studies: Employed to dissect the dual role of TGF-β signaling in tumor suppression and promotion, particularly in metastasis and tumor microenvironment interactions.
• Stem Cell Research: Used to modulate TGF-β signaling to control stem cell differentiation and maintenance in various lineage commitment studies.

Basic Information

Product Name	Sb-505124
CAS No.	356559-13-2
Molecular Formula	C₂₂H₂₂N₄O₃
Molecular Weight	390.44 g/mol
Synonyms	2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride; SB505124; SB-505124; ALK5 Inhibitor II; TGF-β Receptor I Kinase Inhibitor IV; 6-Methyl-2-[5-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-4-yl]pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our Sb-505124 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.