Description

Ki16425 is a potent and selective small-molecule antagonist of lysophosphatidic acid (LPA) receptors, specifically targeting LPA1 and LPA3. This compound is a critical research tool for elucidating the complex signaling pathways of LPA in cellular and physiological processes. It is primarily utilized by researchers and pharmaceutical developers in oncology, fibrosis, and neurobiology to investigate disease mechanisms and validate novel therapeutic targets.

Application

• Biomedical Research: Used as a selective pharmacological probe to study the role of LPA1 and LPA3 receptor signaling in cell proliferation, migration, and survival.
• Cancer Research: Investigated for its potential to inhibit LPA-driven tumor progression, metastasis, and angiogenesis in various cancer models.
• Fibrosis Studies: Applied in research models of pulmonary, renal, and hepatic fibrosis to explore anti-fibrotic effects by blocking LPA-mediated fibroblast activation.
• Neurobiological Research: Utilized to examine LPA's effects on neuropathic pain, neuroinflammation, and neural cell function.
• Drug Discovery: Serves as a reference compound and a starting point for the development of new LPA receptor-targeted therapeutics.
• In Vitro Assay Development: Employed in high-throughput screening and functional assays to characterize LPA receptor activity and identify new modulators.

Basic Information

Product Name	Ki16425
CAS No.	355025-24-0
Molecular Formula	C₂₉H₃₄ClNO₄
Molecular Weight	496.04 g/mol
Synonyms	Ki 16425; Ki-16425; (2S)-3-({[4-[4-({[1-(2-Chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl)propanoic Acid; LPA1/LPA3 Receptor Antagonist; Lysophosphatidic Acid Receptor Antagonist Ki16425; LPAR1/3 Antagonist
EINECS	Contact for details

Quality Control

Our Ki16425 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and structural confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) containing purity, identity, and impurity profiles is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.