Description

3 5-Difluorobenzylzinc Chloride 0.5M is a highly reactive organozinc reagent, a crucial building block for introducing the 3,5-difluorobenzyl moiety into complex molecular architectures. Its value lies in enabling efficient carbon-carbon bond formation, specifically through cross-coupling reactions, which is fundamental for synthesizing advanced intermediates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise functionalization to develop new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing active pharmaceutical ingredients (APIs), especially those containing difluorinated aromatic systems.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the difluorobenzyl group enhances biological activity and stability.
• Cross-Coupling Reactions: Employed in Negishi and related palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds with high selectivity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts.
• Material Science Research: Building block for creating organic electronic materials, liquid crystals, and polymers with tailored properties.
• Fine Chemical Production: Used in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Item	Details
Product Name	3 5-Difluorobenzylzinc Chloride 0.5M
CAS No.	352525-71-4
Molecular Formula	C7H5ClF2Zn
Molecular Weight	223.86 g/mol
Synonyms	(3,5-Difluorobenzyl)zinc chloride; Zinc, chlorobis(3,5-difluorophenyl)methyl-; 3,5-Difluorobenzylzinc chloride solution; (3,5-Difluorophenylmethyl)zinc chloride; 0.5M (3,5-Difluorobenzyl)zinc chloride in THF; Organozinc reagent 352525-71-4
EINECS	Contact for details

Quality Control

Every batch of our 3 5-Difluorobenzylzinc Chloride 0.5M is manufactured and analyzed under strict quality protocols to ensure consistency and reliability for your critical synthesis work. We guarantee the solution concentration, purity, and reactivity profile. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solvent content is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. Due to its properties of being easily oxidized and highly volatile, the container must be kept sealed and handled in a dry, well-ventilated environment to maintain stability and prevent concentration changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Solvent (THF)	Balance
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.