Description

Semapimod is a synthetic guanylhydrazone compound with significant immunomodulatory and anti-inflammatory properties. Its primary value lies in its potent inhibition of macrophage activation and the production of pro-inflammatory cytokines, such as TNF-α. This makes it a critical research-grade chemical for pharmaceutical R&D, particularly in the study of autoimmune diseases, sepsis, and inflammatory bowel disease. Researchers and developers in the global life sciences sector utilize Semapimod CAS NO 352513-83-8 to investigate novel therapeutic pathways.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of immunomodulatory drugs.
• Inflammation & Autoimmune Disease Studies: Used in preclinical research to model and investigate treatments for conditions like rheumatoid arthritis, Crohn's disease, and psoriasis.
• Sepsis and Critical Care Research: Employed to study the suppression of cytokine storms and systemic inflammatory response syndrome (SIRS).
• Immunology Assay Development: Serves as a critical tool compound for validating assays that measure macrophage activity and cytokine inhibition.
• Academic & Institutional Research: Utilized in university and government labs for fundamental research into innate immune system signaling pathways.
• Biotech Product Development: Acts as a starting material or intermediate for companies developing novel biologic or small-molecule therapies targeting inflammation.

Basic Information

Product Name	Semapimod
CAS No.	352513-83-8
Molecular Formula	C₁₉H₂₃N₇O
Molecular Weight	365.44 g/mol
Synonyms	CNI-1493; CPSI-2364; CPSI 2364; CPSI2364; Bisguanylhydrazone; Semapimod hydrochloride; TNF-α Synthesis Inhibitor; Guanylhydrazone derivative; 1,1'-[1,4-Phenylenebis(methylene)]bis[1,2,3,6-tetrahydro-3,6-dioxopyridazine-4-carboxamidine]
EINECS	Contact for details

Quality Control

Our Semapimod is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting all critical quality attributes. We adhere to relevant ISO guidelines to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.