Description

Dl-Cystine-2,2',3,3,3',3'-D6 is a deuterium-labeled isotopologue of the amino acid cystine, specifically designed for use as an internal standard in analytical chemistry. This compound is essential for ensuring the accuracy and precision of quantitative analyses, particularly in mass spectrometry-based methods. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require high-fidelity data for method development, validation, and regulatory compliance.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the accurate quantification of endogenous cystine and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmaceutical Research & Development: Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) studies by enabling precise measurement of drug metabolites and biomarkers.
• Clinical Diagnostics: Supports the development and validation of assays for metabolic disorders, such as cystinuria, by providing a stable isotopic reference.
• Stable Isotope Labeling: Serves as a tracer in metabolic flux analysis and proteomics research to study protein synthesis and turnover rates.
• Method Validation & GLP Compliance: Critical for meeting Good Laboratory Practice (GLP) requirements in analytical method validation, ensuring data integrity and reproducibility.
• Nutraceutical & Food Analysis: Employed in the quality control of amino acid supplements and fortified food products to verify label claims and purity.

Basic Information

Item	Details
Product Name	Dl-Cystine-2,2',3,3,3',3'-D6
CAS No.	352431-53-9
Molecular Formula	C₆H₆D₆N₂O₄S₂
Molecular Weight	246.33 g/mol (approx.)
Synonyms	DL-Cystine-d6; (R,S)-Cystine-d6; (±)-Cystine-d6; 3,3'-Dithiobis(2-aminopropanoic acid)-2,2',3,3,3',3'-d6; Deuterated DL-Cystine; Cystine Internal Standard-d6; Hexadeuterated DL-Cystine; L-Cystine-d6 (racemic mixture)
EINECS	Contact for details

Quality Control

Every batch of Dl-Cystine-2,2',3,3,3',3'-D6 is produced and tested to meet the stringent requirements for isotopic labeling and chemical purity. Our quality assurance protocol includes verification of isotopic enrichment (D-content) by NMR and MS, alongside rigorous chemical purity analysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, isotopic purity, and related substances. We support compliance with GMP, ISO, and ICH guidelines for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a desiccated environment to prevent absorption of moisture, which can affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.