Description

Dl-2-Pyrrolidinone-3,3,4,4,5-D5-5-Carboxylic Acid CAS NO 352431-30-2 is a deuterated derivative of 2-pyrrolidone-5-carboxylic acid, a key lactam-based building block. This compound is specifically engineered for use as a stable isotope-labeled internal standard in advanced analytical chemistry, ensuring unparalleled accuracy in quantitative mass spectrometry. It is an essential material for researchers and developers in the pharmaceutical, agrochemical, and life science sectors who require high-fidelity tracers for metabolism studies, pharmacokinetic profiling, and method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of related analytes in complex biological matrices.
• Metabolite Tracing & Drug Metabolism Studies: Used in pharmaceutical R&D to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Proteomics & Biomarker Research: Enables accurate relative and absolute quantification of proteins and metabolites in discovery workflows.
• Environmental & Food Safety Analysis: Applied in the detection and quantification of trace-level contaminants where high precision is mandated.
• Synthetic Intermediate: Acts as a specialized building block for the synthesis of deuterated analogs of more complex molecules for research purposes.
• Quality Control & Method Development: Essential for developing, validating, and routinely verifying the accuracy of analytical methods in regulatory environments.

Basic Information

Item	Details
Product Name	Dl-2-Pyrrolidinone-3,3,4,4,5-D5-5-Carboxylic Acid
CAS No.	352431-30-2
Molecular Formula	C5H2D5NO3
Molecular Weight	148.16 g/mol (for deuterated form)
Synonyms	DL-2-Pyrrolidone-5-carboxylic-3,3,4,4,5-d5 Acid; 5-Oxo-DL-proline-3,3,4,4,5-d5; (RS)-5-Oxopyrrolidine-2-carboxylic-3,3,4,4,5-d5 Acid; Deuterated PCA; 2-Pyrrolidinone-5-carboxylic-d5 Acid; DL-Pyroglutamic-d5 Acid; 5-Carboxy-2-pyrrolidinone-d5; Glutimide-d5 Acid
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is manufactured and tested under strict quality systems to ensure isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D-content), and absence of critical impurities. Our quality commitment aligns with the stringent requirements for analytical reference standards used in GLP and ISO 17025 accredited laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.