Description

Necrostatin-7 (Nec-7) is a potent and selective small-molecule inhibitor of necroptosis, a form of programmed cell death. This compound is a critical research tool for investigating cell death pathways and their implications in various disease models. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for studying neurodegenerative diseases, ischemic injury, and inflammatory conditions.

Application

• Biomedical Research: A key reagent for studying the molecular mechanisms of necroptosis and its role in disease pathology.
• Drug Discovery: Used in high-throughput screening and target validation for developing novel therapeutics targeting regulated cell death.
• Neurodegenerative Disease Studies: Investigated in models of Alzheimer's disease, Parkinson's disease, and ALS to understand and potentially mitigate neuronal cell death.
• Ischemia-Reperfusion Injury Research: Applied in studies of myocardial infarction, stroke, and organ transplantation to assess protective effects against tissue damage.
• Inflammatory Condition Models: Used to dissect the contribution of necroptosis to diseases like sepsis, inflammatory bowel disease, and psoriasis.
• Academic & Institutional Laboratories: Serves as a standard compound for cell biology and biochemistry research focused on cell death signaling pathways.

Basic Information

Product Name	Necrostatin-7 (Nec-7)
CAS No.	351062-08-3
Molecular Formula	C₁₃H₁₃N₃O₂
Molecular Weight	243.26 g/mol
Synonyms	Nec-7; 1H-Indole-3-carboxamide, 1-(4-nitrophenyl)-; 1-(4-Nitrophenyl)-1H-indole-3-carboxamide; Necrostatin 7; Necrostatin-7; Z-VAD-FMK negative control (in some contexts); RIP1 kinase inhibitor (context-dependent)
EINECS	Contact for details

Quality Control

Our Necrostatin-7 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via NMR and mass spectrometry. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.