Description

2-Fluoropyridine-5-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated pyridine derivatives with potential biological activity.
• Agrochemical Research: Used to construct novel herbicide and pesticide candidates by introducing the fluoropyridine moiety into lead structures.
• Ligand Synthesis: Serves as a starting material for creating specialized bidentate or tridentate ligands used in catalysis.
• Material Science: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic systems are advantageous.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or inhibitors for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	2-Fluoropyridine-5-Boronic Acid
CAS No.	351019-18-6
Molecular Formula	C5H5BFNO2
Molecular Weight	140.91 g/mol
Synonyms	(5-Borono-2-fluoropyridine); 2-Fluoro-5-pyridineboronic acid; (2-Fluoropyridin-5-yl)boronic acid; 2-Fluoro-5-pyridinylboronic acid; 5-Borono-2-fluoropyridine; 2-Fluoropyridine-5-boronic acid pinacol ester (common derivative); 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoropyridine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and 1H/11B/19F NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and relevant physical data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.