Description

4-Fluoro-3-Methylphenyl Isothiocyanate is a versatile aromatic isothiocyanate derivative that serves as a critical building block in advanced organic synthesis. Its reactive isothiocyanate group enables efficient derivatization, making it essential for constructing complex molecular architectures. This high-purity intermediate is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its fluorine and methyl substituents for bioactivity.
• Ligand and Chelator Preparation: Serves as a starting material for creating specialized ligands used in catalysis and metal complexation studies.
• Material Science Research: Employed in the synthesis of functional polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes for enzyme studies due to its electrophilic reactivity.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	4-Fluoro-3-Methylphenyl Isothiocyanate
CAS No.	351003-66-2
Molecular Formula	C8H6FNS
Molecular Weight	167.20 g/mol
Synonyms	3-Methyl-4-fluorophenyl isothiocyanate; 4-Fluoro-m-tolyl isothiocyanate; 1-Fluoro-2-methyl-4-isothiocyanatobenzene; (4-Fluoro-3-methylphenyl) isothiocyanate; Isothiocyanic acid, 4-fluoro-3-methylphenyl ester; 4-Fluoro-3-methylbenzenisothiocyanate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methylphenyl Isothiocyanate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under a dry inert atmosphere for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.