Description

5-Chloro-2-Fluorobenzenesulfonyl Chloride is a versatile and highly reactive organosulfur compound primarily used as a key synthetic intermediate. Its value lies in the sulfonyl chloride functional group, which readily undergoes nucleophilic substitution to form sulfonamides and sulfonate esters, making it a critical building block in advanced chemical synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct sulfonylurea or sulfonamide herbicides and fungicides, contributing to crop protection solutions.
• Material Science: Serves as a monomer or cross-linking agent for creating specialized polymers with specific surface properties or ionic conductivity.
• Dye and Pigment Manufacturing: Employed in the production of sulfonated dyes and colorants to enhance solubility and fiber affinity.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in exploring new synthetic pathways and molecular entities.
• Ligand and Catalyst Preparation: Used to synthesize specialized ligands for metal complexes or to functionalize catalytic surfaces.

Basic Information

Product Name	5-Chloro-2-Fluorobenzenesulfonyl Chloride
CAS No.	351003-49-1
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.06 g/mol
Synonyms	2-Fluoro-5-chlorobenzenesulfonyl chloride; 1-Chloro-4-fluoro-3-sulfonylchloridebenzene; 5-Chloro-2-fluorobenzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 5-chloro-2-fluoro-; 3-Chloro-6-fluorobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluorobenzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.